Research Priorities: top 10s
This page lists the top 10 research priorities, shared by patients, carers and clinicians, for each completed JLA Priority Setting Partnership.
1. What management strategy should be adopted for the treatment of acne in order to optimise short and long-term outcomes?
2. What is the correct way to use antibiotics in acne to achieve the best outcomes with least risk?
3. What is the best treatment for acne scars?
4. What is the best way of preventing acne?
5. What is the correct way to use oral isotretinoin (Roaccutane) in acne in order to achieve the best outcomes with least risk of potentially serious adverse effects?
6. Which lifestyle factors affect acne susceptibility or acne severity the most and could diet be one of them?
7. What is the best way of managing acne in mature women who may/may not have underlying hormonal abnormalities?
8. What is the best topical product for treating acne?
9. Which physical therapies including lasers and other light based treatments are safe and effective in treating acne?
10. How long do acne treatments take to work and which ones are fastest acting?
1a. What are the adverse effects associated with long term use of short and long actingbronchodilators; inhaled and oral steroids; and combination and additive therapies in adults? (N.B this includes children aged 12 years old and over)
1b. What are the adverse effects associated with long term use of short and long acting bronchodilators; inhaled and oral steroids; and combination and additive therapies in children?
2. What is the most effective way of managing asthma with other health problems?
3. What are the key components of successful "Self Management" for a person with asthma?
4. What is the most effective strategy to educate people with asthma and health professionals about managing the adverse effects of drug therapies?
5. What is the most effective way of managing asthma triggers?
6. What is the role of complementary therapies in asthma management?
7. What are the benefits of breathing exercises as a form of physical therapy for asthma?
8. What type of patient (children and adults) and health professional education is most effective in gaining asthma control?
9. What is the most effective way to manage consultations and asthma control in adolescence and young people?
10. Psychological interventions for adults with asthma?
1. What types of psychological intervention (individual therapy, community or school
based) and at what time (from diagnosis to adulthood) are most helpful for patients with
a cleft of the lip and/or palate and their families?
2. What are the educational, employment and personal (eg relationships) outcomes for individuals with a cleft of the lip and/or palate during childhood, adolescence and in the long term?
3. What is the best protocol for primary repair of both the lip and palate, including technique/timing and sequence?
4. In individuals with a cleft of the lip and/or palate when is the most effective age to begin speech therapy?
5. What is the best treatment for otitis media with effusion (glue ear) in individuals with a cleft of the lip and/or palate?
6. Can stem cells be used to improve palate repair (both primary and secondary)?
7. What interventions would enhance the educational outcomes for children with a cleft of
the lip and/or palate?
8. What is the impact of having a baby born with a cleft of the lip and/or palate on maternal/child attachment?
9. What is the best way to manage infants with a cleft of the lip and/or palate undergoing primary surgery before, during and after hospital Eg. Fluids, pain control, antibiotics, probiotics, arm splints, feeding practices?
10. What are the genetic and environmental causes of clefts of the lip and/or palate?
11. How can we improve the diagnosis of cleft palate (without cleft lip)?
12. What is the best way to prevent tooth decay in children with a cleft of the lip and/or palate?
1. What are the most effective components of care that keep a person with dementia as independent as they can be at all stages of the disease in all care settings?
2. How can the best ways to care for people with dementia, including results from research findings, be effectively disseminated and implemented into care practice?
3. What is the impact of an early diagnosis of dementia and how can primary care support a more effective route to diagnosis?
4. What non-pharmacological and/or pharmacological (drug) interventions are most effective for managing challenging behaviour in people with dementia?
5. What is the best way to care for people with dementia in a hospital setting when they have acute health care needs?
6. What are the most effective ways to encourage people with dementia to eat, drink and maintain nutritional intake?
7. What are the most effective ways of supporting carers of people with dementia living at home?
8. What is the best way to care for people with advanced dementia (with or without other illnesses) at the end of life?
9. When is the optimal time to move a person with dementia into a care home setting and how can the standard of care be improved?
10. What are the most effective design features for producing dementia friendly environments at both the housing and neighbourhood levels?
1. What is the best way to enhance communication between health care professionals and patients and to maximize patient participation in decision-making with regards to the advantages and disadvantages of different forms of dialysis, and access to test results to facilitate self-management?
2. How do different dialysis modalities compare in terms of their impact on quality of life, mortality and patient acceptability, and are there specific patient factors that make one modality better for some patients with kidney failure than others?
3. What are the causes and effective treatment(s) of, and ways to prevent, itching in dialysis patients?
4. What is the best strategy to increase kidney transplantation; including access to transplantation, increasing the efficiency of the recipient workup, and increasing the availability of donor kidneys?
5. What is the psychological and social impact of kidney failure on patients, their family, and other caregivers, and can this be reduced?
6. What are the best ways to promote heart health in dialysis patients, including management of blood pressure?
7. For people with kidney failure, what is the impact of each of the dietary restrictions (sodium, potassium, phosphate) separately, and when taken in combination, on important outcomes including quality of life?
8. What are the best ways to manage symptoms in people on or nearing dialysis including poor energy, nausea, cramping, and restless legs?
9. What are the causes and effective treatment(s) of depression in dialysis patients?
The uncertainties were expressed nearly equally by patients and health professionals. There were concerns about the emotional effects of dialysis on the patient; how to manage mood changes and depression, and what may be responsible for depression – i.e. the side effects of medications or other treatments, or kidney disease itself.
10. What is the best vascular access (among both new and existing types of access) for people on hemodialysis?
1. What is the optimal process for GP education and training for improved diagnosis and management of balance disorders?
2. What is the best way of training health professionals in the management of balance disorders?
3. What is the most effective treatment for Vestibular migraine?
4. What are the best interventions to improve balance/minimise symptoms in daily activities such as supermarkets, escalators etc.?
5. Is any specific surgical intervention effective in Ménière's disease and what procedure is best?
6. Are there any effective interventions for the ear pressure symptoms in Ménière's disease?
7. What is the optimum pharmacological strategy for the management of patients with Ménière's disease? In particular, what are the effects of betahistine (including long term effects)?
8. Is it helpful in preventing the severity, frequency and progression of attacks of Ménière's disease to adopt a specific diet, or restrict salt, caffeine or fluid intake?
9. Are the home-based exercises given to patients with balance disorders effective?
10. Are stress management techniques helpful in patients with balance disorders?
What is the best and safest way of using topical steroids for eczema: frequency of application, potency, length of time, alternating with other topical treatments, and age limits for treatment?
What is the long term safety of applying steroids to the skin for eczema?
What role might food allergy testing play in treating eczema?
Which emollient is the most effective and safe in treating eczema?
Patient and Carer Priorities:
What is the best psychological treatment for itching/scratching in eczema?
Which is the best way for people with eczema to wash: frequency of washing, water temperature, bath versus shower?
What are the best and safest natural products to apply to the skin for eczema?
How much does avoidance of irritants and allergens help people with eczema?
What is the role of diet in treating eczema: exclusion diets and nutritional supplements?
Healthcare Professional Priorities:
Which is more effective in the management of eczema: education programmes, GP care, nurse-led care, dermatologist-led care or multi-disciplinary care?
Which is safer and more effective for treating eczema: steroids or calcineurin inhibitors?
How effective are interventions to reduce skin infections in the management of eczema?
Which should be applied first when treating eczema, emollients or topical steroids?
What is the best and safest way of using drugs that suppress the immune system when treating eczema?
1. What is the most effective and safe group of oral treatments in treating Hidradenitis Suppurativa (HS)? (e.g. antibiotics, hormonal treatments, retinoids, immunosuppressants, metformin, steroids)
2. What is the best management of an acute flare?
3. What is the impact of HS and the treatments on people with HS? (physical, psychological, financial, social, quality of life)
4. How effective are biologics (etanercept, adalimumab, infliximab, ustekinumab) in treating HS
5. Does early diagnosis and aggressive treatment influence the course of HS?
6. What is the best surgical procedure to perform in treating HS e.g. incision & drainage, local excision, wide excision?
7. Which factors are useful in determining the prognosis (disease progression) of HS?
8. What is the best method of wound care after surgery or for active disease? (e.g. skin grafts, secondary intention, dressings)
9. To what extent is HS caused by genetic factors?
10. What is the best management of pain associated with HS?
• What is the best treatment for children and adults presenting with a) early Lyme disease without neurological involvement and not including erythema migrans and b) late Lyme disease of any manifestation? To include consideration of drug(s), dose, duration.
• What key questions (clinical and epidemiological) should be considered to help make a diagnosis of Lyme disease in children and adults in the UK and would a weighting table be useful?
• How effective are the current UK tests in detecting infections due to the genospecies and strains of B burgdorferi sl in the UK and which single test and what combination of tests performs best in diagnosing or ruling out active Lyme disease. Should stage of the disease and patient age be taken into account when interpreting these tests?
• What are the outcomes of cases where long term treatment has been used?
• What is the optimal course of action if symptoms relapse after a treatment course is finished?
• What is the optimal course of action if symptoms persist after initial treatment: should antibiotic treatment be continued until all symptoms have resolved or should a different dose or different antibiotic be used and what is the course of action if treatment appears to fail completely?
• Are continuing symptoms following conventional recommended treatment due to continued infection, or an immune response or other process?
• How common is relapse and treatment failure and is it related to disease stage, gender, co-infections or any other factor?
• Are there long-term consequences if treatment is delayed?
• Can Lyme be transmitted via other means: person to person sexually, transplacentally or by breast feeding; through organ donation; through blood transfusion?
1. Which treatments are effective to slow, stop or reverse the accumulation of disability associated with MS
2. How can MS be prevented?
4. How can people with MS be best supported to self-manage their condition?
5. Does early treatment with aggressive disease modifying drugs improve the prognosis for people with MS?
6. Is vitamin D supplementation an effective disease modifying treatment for MS?
7. Which treatments are effective to improve mobility for people with MS?
8. Which treatments are effective to improve cognition in people with MS?
9. Which treatments are effective for pain in people with MS?
10. Is physiotherapy effective in reducing disability in people with MS?
1. How effective is repositioning in the prevention of pressure ulcers?
2. How effective at preventing pressure ulcers is involving patients, family and lay carers in patient care?
3. Does the education of health and social care staff on prevention lead to a reduction in the incidence of pressure ulcers and, if so, which are the most effective education programmes (at organisational and Health/Social Care level)?
4. What is the relative effectiveness of the different types of pressure relieving beds, mattresses, overlays, heel protectors and cushions (including cushions for electric and self-propelling wheelchairs) in preventing pressure ulcers?
5. What impact do different service models have on the incidence of pressure ulcers including staffing levels, continuity of care [an on-going relationship with same staff members] and the current organisation of nursing care in hospitals?
6. What are the best service models (and are they sufficiently accessible) to ensure that patients with pressure ulcers receive the best treatment outcomes (including whether getting people with pressure ulcers and their carers more involved in their own pressure ulcer management improves ulcer healing and if so, the most effective models of engagement)?
7. For wheelchair users sitting on a pressure ulcer, how effective is bed rest in promoting pressure ulcer healing?
8. How effective are wound dressings in the promotion of pressure ulcer healing?
9. Does regular turning of patients in bed promote healing of pressure ulcers?
10. Does improving diet (eating) and hydration (drinking) promote pressure ulcer healing?
11. How effective are surgical operations to close pressure ulcers?
12. How effective are topical skin care products and skin care regimes at preventing pressure ulcers?
1. How can over-treatment for prostate cancer be prevented by indentifying and excluding the treatment of harmless tumours?
2. Is there a genetic marker for prostate cancer that would be both more sensitive and more specific than PSA serum level?
3. What can be done to delay or prevent the onset of hormone independent prostate cancer?
4. Are there any dietary measures that can prevent prostate cancer or slow its progression?
5. Does serial PSA measurement in patients with prostate cancer accurately monitor disease progression?
6. Would prostate cancer screening targeted at high risk groups, i.e. those with positive family history, and ethnic minorities with higher rates, improve the outcomes of treatment in these groups?
7. Does active surveillance work for treatment of prostate cancer?
8. Is there a vaccine that can prevent prostate cancer?
9. Do variations in GP awareness of prostate cancer affect outcomes?
10. Are there any non-intrusive diagnostic tests that will identify aggressive prostate cancers whilst not identifying harmless cancers?
11. What is the effectiveness of new treatments for prostate cancer such as High Intensity Focused Ultrasound (HIFU) and Cryotherapy?
1. What is the best way to treat people with schizophrenia that is unresponsive to treatment?
2. What training is needed to recognize the early signs of recurrence?
3. Should there be compulsory community outpatient treatment for people with severe mental disorders?
4. How can sexual dysfunction due to antipsychotic-drug therapy be managed?
5. What are the benefits of supported employment for people with schizophrenia in terms of quality of life, self esteem, long-term employment prospects and illness outcomes?
6. Do the adverse effects of antipsychotic drugs outweigh the benefits?
7. What are the benefits of hospital treatment compared with home care for psychotic episodes?
8. What are the clinical benefits and cost-effectiveness of monitoring the physical health of people with schizophrenia?
9. What are the clinical, social and economic outcomes — including quality of life and the methods and effects of risk monitoring — of treatment by acute day hospitals, assertive outreach teams, in-patient units, and crisis resolution and home treatment teams?
10. What interventions could reduce weight gain in schizophrenia?
Priorities for Age Related Macular Degeneration (AMD) research
1. Can a treatment to stop dry AMD progressing and/or developing into the wet form be devised?
2. What is the cause of AMD?
3. How can AMD be prevented?
4. Are there ways of restoring sight loss for people with AMD?
5. Can the development of AMD be predicted?
6. What is the most effective way to detect and monitor the progression of early AMD?
7. What factors influence the progression of AMD?
8. Can a non-invasive therapy be developed for wet AMD?
9. Can dietary factors, nutritional supplements, complementary therapies or lifestyle changes prevent or slow the progression of AMD?
10. What are the best enablement strategies for people with AMD?
Priorities for Cataract research
1. How can cataracts be prevented from developing?
2. Can the return of cloudy or blurred vision after cataract surgery known as posteriorcapsule opacity (PCO) or secondary cataract be prevented?
3. How can cataract progression be slowed down?
4. What alternatives to treat cataracts other than cataract surgery are being developed?
5. What is the cause of cataract?
6. How can cataract surgery outcomes be improved?
7. How safe and effective is laser assisted cataract surgery?
8. Should accommodative lenses be developed for cataract surgery?
9. What is the best measure of visual disability due to cataract?
10. Can retinal detachment be prevented after cataract surgery?
11. What are the outcomes for cataract surgery among people with different levels of cognitive impairment (whatever the cause but including dementia, stroke, neurological conditions, head injuries)?
Priorities for Childhood Onset Disorders research
1. How can cerebral visual impairment be identified, prevented and treated in children?
2. How can treatment for visual pathway damage associated with pre-term birth be developed?
3. How do we improve screening and surveillance from the ante-natal period through to childhood to ensure early diagnosis of impaired vision and eye conditions?
4. Can the treatment of amblyopia be improved to produce better short and long term outcomes than are possible with current treatments?
5. How can cataract be prevented in children?
6. What are the causes of coloboma and microphthalmia/anophthalmia and how can they be prevented?
7. Can vision be corrected in later life for people with amblyopia?
8. How can retinoblastoma be identified, prevented and treated in children?
9. Can better treatments for glaucoma in children be developed?
10. Can a treatment be developed to improve vision for people with albinism?
Priorities for Corneal and External Eye Conditions research
1. Can new therapies such as gene or stem cell treatments be developed for corneal diseases?
2. What is the most effective management for dry eye and can new strategies be developed?
3. Can treatments to save eye sight from microbial keratitis be improved?
4. How can the rejection of corneal transplants be prevented?
5. Can the outcomes of corneal transplantation be improved?
6. What causes keratoconus to progress and can progression be prevented?
7. Can non-surgical therapy be developed for Fuchs' corneal dystrophy?
8. Can corneal infections be prevented in high-risk individuals such as contact lens wearers?
9. What is the cause of keratoconus and can it be prevented?
10. What is the most effective management of ocular complications associated with Stevens Johnson Syndrome?
11. Can severe ocular surface disease in children, such as blepharokeratoconjunctivitis and vernal keratoconjunctivitis be managed better?
Priorities for Glaucoma research
1. What are the most effective treatments for glaucoma and how can treatments be improved?
2. How can loss of vision be restored for people with glaucoma?
3. How can glaucoma be stopped from progressing?
4. What can be done to improve early diagnosis of sight-threatening glaucoma?
5. What causes glaucoma?
6. What is the most effective way of monitoring the progression of glaucoma?
7. How can glaucoma patients with a higher risk to progress rapidly be detected?
8. Why is glaucoma more aggressive in people of certain ethnic groups, such as those of West African origin?
9. How can glaucoma be prevented?
10. Is there a link between treatment adherence and glaucoma progression and how can adherence be improved?
Priorities for Inherited Retinal Disease research
1. Can a treatment to slow down progression or reverse sight loss in inherited retinal diseases be developed?
2. How can sight loss be prevented in an individual with inherited retinal disease?
3. Is a genetic (molecular) diagnosis possible for all inherited retinal diseases?
4. What factors affect the progression of sight loss in inherited retinal diseases?
5. What causes sight loss in inherited retinal diseases?
6. What is the most effective way to support patients with inherited retinal disease?
7. Can the diagnosis of inherited retinal diseases be refined so that individuals can be given a clearer idea about their specific condition and how it is likely to progress?
8. What is the relationship between sight loss and mental health for people with inherited retinal diseases?
9. Would having a treatment for an inherited retinal disease preclude a patient from having another treatment?
10. With regard to inherited retinal disease what is the role of pre-natal and pre-implantation diagnosis in helping parents make informed choices?
Priorities for Neuro-ophthalmology research
1. What is the underlying cause of optic nerve damage in optic neuropathies, such as anterior ischaemic optic neuropathy, Leber's hereditary optic neuropathy, optic neuritis and other optic neuropathies?
2. What are the most effective treatments and rehabilitation for optic neuropathies, e.g. Leber's hereditary optic neuropathy and anterior ischaemic optic neuropathy?
3. Can vision loss due to optic nerve diseases such as giant cell arteritis, Leber's hereditary optic neuropathy, optic neuritis and optic atrophy, be restored, for example through gene therapy and stem cell treatment?
4. What rehabilitation or treatment methods are most effective for vision loss following brain damage due to stroke, brain injury, cerebral vision impairment, tumours and dementias?
5. What is the most effective way to assess vision in patients with neurological visual impairment i.e. stroke, dementia and cerebral/cortical visual impairment?
6. Can the early stages of optic neuropathy be detected?
7. How can optic neuropathies be prevented, for example anterior ischaemic optic neuropathy, Leber's hereditary optic neuropathy, optic neuritis and other optic neuropathies?
8. Can treatments be developed for visual field and ocular motility manifestations following stroke?
9. How can electronic devices improve or restore vision for people with optic neuropathies?
10. Can an alternative or new treatment be developed that will treat the sight loss caused by giant cell arteritis?
Priorities for Ocular Cancer research
1. What can be done to help ocular cancer sufferers?
2. Can gene-based targeted therapies for ocular cancers be developed?
3. How can immunotherapy be used to fight metastatic ocular melanoma?
4. What are the most effective detection and screening methods for follow-up to detect metastasis of ocular melanoma?
5. How can follow-up for ocular complications be managed in patients with ocular melanoma?
6. What is the best management of metastatic choroidal melanoma?
7. What activates choroidal melanoma metastasis in the liver after the primary melanoma has been treated?
8. Can adjuvant therapies be developed to treat ocular melanoma?
9. What are the causes of ocular cancer and how can they be prevented?
10. What is the most effective treatment for primary ocular melanoma?
Priorities for Ocular Inflammatory Disease research
1. What are the most effective treatments for ocular and orbital inflammatory diseases?
2. What causes thyroid eye disease?
3. Can the severity of ocular and orbital inflammatory disease in an individual be predicted?
4. Is it possible to prevent further occurrences of retinal damage caused by toxoplasmosis?
5. What causes birdshot retinopathy?
6. Why does disease burn out in patients with ocular and orbital inflammatory diseases?
7. Can early detection methods be developed for ocular and orbital inflammatory diseases?
8. What medications best prevent the development of eye disease in Behcets?
9. What causes scleritis?
10. Can diet or lifestyle changes prevent uveitis from developing?
Priorities for Refractive Error and Ocular Motility
1. What factors influence the development of refractive error (myopia, astigmatism, presbyopia, and long-sightedness)?
2. What is the cause of both congenital and acquired nystagmus?
3. How can the development of binocular vision in young children with squint and amblyopia be promoted, and would the same approach work in older individuals without inducing intractable diplopia?
4. Would correction of refractive error have a positive impact on early life learning and development?
5. Does early diagnosis of refractive error improve long-term prognosis and promote faster, more effective treatment?
6. What is the effect of congenital nystagmus on visual and emotional development?
7. What is the most effective treatment for exotropia and when should it be delivered?
8. How can the functional effects of surgical treatment for squint be best assessed?
9. Could the accurate testing of refractive error be made less dependent on a subjective response, i.e. the person's own response?
10. How can myopia be prevented?
Priorities for Retinal Vascular Disease research
1. What are the best methods to prevent retinopathy of prematurity?
2. How can sight loss from diabetic retinal changes be prevented and reduced?
3. What are the predictive factors for the progression to sight threatening diabetic eye disease?
4. Is there a way to improve screening of premature babies for retinopathy of prematurity?
5. Can an effective long lasting treatment for diabetic macular oedema, both ischaemic and non-ischaemic, be developed?
6. Can a retinal vein occlusion be predicted and prevented?
7. Can new non-invasive treatments be developed to slow down the progression of diabetic retinopathy?
8. What are the barriers that prevent diabetic patients having regular eye checks?
9. What rehabilitation programmes are best for the management of distorted vision from retinal diseases?
10. What is the efficacy and safety of anti-VEGF agents in the treatment of retinopathy of prematurity?
Priorities for Vitreoretinal/Ocular Trauma research
1. How can surgical techniques be improved to save sight for eyes damaged by injury?
2. How can the risk of losing sight for people with retinal detachment be reduced?
3. How can better interventions be developed that are effective in treating vitreous opacities/eye floaters?
4. What causes retinal detachment and can it be prevented?
6. Can a functioning prosthetic eye be developed to replace an eye damaged by injury?
7. How can epiretinal membrane/fibrosis be prevented or treated?
8. Can stem cells be used to regrow an eye or part of an eye?
9. What causes posterior vitreous detachment/vitreous syneresis?
10. Are there methods to prevent and improve the treatment of macular holes?
1. What are the best ways to improve cognition after stroke?
2. What are the best ways of helping people come to terms with the long term consequences of stroke?
3. What are the best ways to help people recover from aphasia?
4. What are the best treatments for arm recovery and function, including visual feedback, virtual reality, bilateral training, repetitive task training, imagery/mental practice, splinting, electromechanical and robot-assisted arm training and botulinum toxin.
5. What are the best ways to treat visual problems after stroke?
6. What are the best ways to manage and/or prevent fatigue?
7. What are the best treatments to improve balance, gait and mobility, including physiotherapy, gait rehabilitation, visual and auditory feedback, electrical stimulation, different types of ankle foot orthoses and electromechanical assisted gait training?
8. How can stroke survivors and families be helped to cope with speech problems?
9. What are the best ways to improve confidence after stroke, including stroke clubs/groups, offering support, one-to-one input and re-skilling?
10. Are exercise and fitness programmes beneficial at improving function and quality of life and avoiding subsequent stroke?
- What management strategies are more effective than a usual model of audiological care in improving outcomes for people with tinnitus?
- Is Cognitive Behaviour Therapy (CBT), delivered by audiology professionals, effective for people with tinnitus? Here comparisons might be with usual audiological care or CBT delivered by a psychologist.
- What management strategies are more effective for improving tinnitus-related insomnia than a usual model of care?
- Do any of the various available complementary therapies provide improved outcome for people with tinnitus compared with a usual model of care?
- What type of digital hearing aid or amplification strategy provides the most effective tinnitus relief?
- What is the optimal set of guidelines for assessing children with tinnitus?
- How can tinnitus be effectively managed in people who are Deaf or who have a profound hearing loss?
- Are there different types of tinnitus and can they be explained by different mechanisms in the ear or brain?
- What is the link between tinnitus and hyperacusis (over-sensitivity to sounds)?
- Which medications have proven to be effective in tinnitus management compared with placebo?
The following question was carefully deliberated and just fell outside of the top ten, however participants in the final meeting felt it was worthy of a special mention:
- Does stem cell technology (e.g. for hair cell regeneration) provide an effective pipeline to develop new medical interventions for treating
Overarching research aspiration: An effective cure for type 1 diabetes
1. Is it possible to constantly and accurately monitor blood sugar levels, in people with type 1 diabetes, with a discrete device (non-invasive or invasive)
2. Is insulin pump therapy effective? (immediate v deferred pump, and comparing outcomes with multiple injections)
3. Is an artificial pancreas for type 1 diabetes (closed loop system) effective?
4. What are the characteristics of the best type 1 diabetes patient education programmes (from diagnosis to long term care) and do they improve outcomes?
5. What are the cognitive and psychological effects of living with type 1 diabetes?
6. How can awareness of and prevention of hypoglycaemia in type 1 diabetes be improved?
7. How tightly controlled do fluctuations in blood glucose levels need to be to reduce the risk of developing complications in people with type 1 diabetes?
8. Does treatment of type 1 diabetics by specialists (e.g. doctors, nurses, dieticians, podiatrists, ophthalmologists and psychologists) trained in person-centred skills provide better blood glucose control, patient satisfaction and self-confidence in management of type 1 diabetes, compared to treatment by non specialists with standard skills?
9. What makes self management successful for some people with type 1 diabetes, and not others?
10. Which insulins are safest and have the fewest long term adverse effects?
1. What are the optimal pelvic floor muscle training protocols (frequency and duration of therapy) for the treatment of different patterns of urinary incontinence?
2. Can guidance or training for general practitioners on appropriate pathways of care improve the management of patients with urinary incontinence?
3. What is best practice for the treatment of combined stress urinary incontinence and detrusor overactivity?
4. What catheter regimens are most effective in preventing urinary tract infections in patients using intermittent self-catheterisation for the management of a neurogenic bladder?
5. Which treatment is most effective for the reduction of urinary frequency and urgency?
6. Is urodynamic testing prior to surgery for urinary incontinence associated with better continence rates and quality of life than surgery indicated without such testing?
7. What is best practice for the management of stress urinary incontinence following failed tension free vaginal tape surgery?
8. What are the most effective treatments of daytime urinary incontinence in children?
9. Are disposable catheters more or less acceptable than reusable catheters in terms of effective bladder management, patient experience and urinary tract infections?
10. In women with prolapse (symptomatic or asymptomatic) and SUI, should suburethral tapes be inserted at the same time as repairing the prolapse?
1. How effective are systemic immunosuppressants in treating vitiligo?
2. How much do psychological interventions help people with vitiligo?
3. Which treatment is more effective for vitiligo: light therapy or calcineurin inhibitors?
4. How effective is ultraviolet B therapy when combined with creams or ointments in treating vitiligo?
5. What role might gene therapy play in the treatment of vitiligo?
6. How effective are hormones or hormone-related substances that stimulate pigment cells (melanocyte-stimulating hormone analogues, afamelanotide) in treating vitiligo?
7. Which treatment is more effective for vitiligo: calcineurin inhibitors or steroid creams/ointments?
8. Which treatment is more effective for vitiligo: steroid creams/ointments or light therapy?
9. How effective is the addition of psychological interventions to patients using cosmetic camouflage for improving their quality of life?
10. How effective is pseudocatalase cream (combined with brief exposure to ultraviolet B) in treating vitiligo?
In addition, two treatment uncertainties were suggested as ‘ones to watch’, as these interventions were still in an early investigative stage.
11. How effective is piperine (black pepper) cream in treating vitiligo?
12. What role might stem cell therapy play in treating vitiligo?