How can clinical trialists serve the needs of clinicians and patients more effectively?

A meeting organised jointly by the James Lind Alliance and The Lancet
Held at the Royal Society of Medicine, London, on 25 June 2007

The meeting was convened by the James Lind Alliance and the Lancet to address whether the right trials are being carried out, if the right questions are being asked, if the trials are done in the right way, if they are looking at the right outcomes and to discuss evidence to help individualise treatment decisions.

For a report of this event 'Patients and the Future of Clinical Trials' published by HSCNEWS INTERNATIONA issue 38, click here (PDF)

Other Articles relating to the event as follows:
‘Research for real questions’ Margaret McCartney,FT click here (PDF)
'Clinical trial results often overstate benefits of treatment' Michael Day, BMJ.com 2007;334:1341 Click here (PDF)

Presentation abstracts and slides are available below:

Morning Session: “DOING THE RIGHT TRIALS – RIGHT QUESTIONS, RIGHT OUTCOMES, RIGHT WAY”

Chair:
Iain Chalmers, Coordinator, Database of Uncertainties about the Effects of Treatment

“How can clinical trialists serve the needs of clinicians better?”
[slides – PPS 1,927 kb – abstract– PDF]
David Tovey, Editorial Director, BMJ Knowledge

“How can clinical trialists serve the needs of patients better?”
[slides not available – abstract PDF]
Hilda Bastian, Head, Patient Information and Research, Institute for Quality and Efficiency in Healthcare, Germany

“The need for trials reflecting the real world of clinical practice”
[slides – PPS 1,475 kb – abstract PDF]
Stephen Holgate, Professor, University of Southampton and Southampton Universities HT (NHS)

“Comparisons of patients’, clinicians’ and researchers’ agendas”
[slides – PPS 911 kb – abstract – PDF]
Sandy Oliver, Reader, Social Science Research Unit, Institute of Education, London

“Identifying research priorities in the UK Clinical Research Network”
[slides – PPS 106 kb – abstract PDF]
Janet Darbyshire, Joint Director UKCRN and Director, UK Clinical Trials Unit

Afternoon session: “EVIDENCE TO HELP INDIVIDUALISE TREATMENT DECISIONS”

Chair :
Richard Horton, Editor, The Lancet

“Challenges for a general practitioner and medical columnist”
[slides – PPS 154 kb – abstract PDF]
Margaret McCartney, General Practitioner and Financial Times Columnist

“Use of subgroup analysis and risk modelling”
[slides – PPS 1,479 kb – abstract – PDF]
Peter Rothwell, Professor of Clinical Neurology, University of Oxford

“Individualising treatment decisions in primary care”
[slides not available – abstract PDF]
Paul Glasziou, Professor of Evidence-Based Medicine, University of Oxford

“Individualising treatment decisions for acute vascular syndromes”
[slides – PPS 4,437 kb – abstract PDF]
David Kent, Institute for Clinical Research and Health Policy Studies, Tufts-New England Medical Center, Boston, USA

“The case for routine availability of individual patient data”
[slides not available – abstract PDF]
Doug Altman, Director, Centre for Statistics in Medicine, University of Oxford

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